gdp dissociation inhibitor meaning in English

gdp解离抑制因子

Rab7 mediates transport of proteins from early endosome to late endosome or fusion of early endosome with late endosome , while rab9 mediates the retransport of m6pr from late endosome to trans - golgi network . the gtp / gdp - binding ability and intrinsic gtpase activity of rab proteins make them exist in rab - gtp or rab - gdp status . the switching of rabs between gtp - bound ( active ) and gdp - bound ( inactive ) forms requires other regulatory proteins , including guanosine exchange factor ( gef ) , gdp dissociation inhibitor ( gdi ) and gtpase activating protein ( gap ) , and lays the foundations of rab function
Rab蛋白家族成员和其他小g蛋白一样可以结合gtp gdp ，在自身gtp酶的水解作用和其他蛋白( gef 、 gap 、 gdi )的调节作用下发生gtp (活化状态)和gdp (无活性)结合形式的转变；同时rab蛋白也在膜结合性( membrane - bound )和胞浆可溶性( cytosolic )之间变化，一个变化过程对应着一个功能循环，接着rab蛋白回到初始状态参与下一个循环。